The Manufacture of Veterinary Clostridial Vaccine
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چکیده
Production of clostridial vaccines involves growing the organism (clostridial bacteria) in a growth medium to produce large amounts of toxins, and altering the toxins so that they are no longer toxic, toxoids. These toxoids become antigens which the immune system recognises and hence produces antibodies to act against genuine toxins. After cultivation the live bacteria in the culture must be deactivated, and the resulting mixture is diluted and mixed with an adjuvant, a substance which improves the immune response to the toxoids.
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Background: Clostridium chauvoei is the etiological agent of blackleg as an endogenous infection in cattle. Flagella have been known to play a critical role in the protective immunity of animals to clostridial infections. C.chauvoei has two copies of fliC gene, namely fliA and fliB. OBJECTIVES: The aim of this study was the determination and nucleotide sequence analysis of both copies of fliC ...
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